Publications

Evaluation and Design of Genome-wide CRISPR/Cas9 Knockout Screens
Traver Hart, Amy Tong, Katie Chan, Jolanda van Leeuwen, Ashwin Seetharaman, Michael Aregger, MeghaChandrashekhar, Nicole Hustedt, Sahil Seth, Avery Noonan, Andrea Habsid, Olga Sizova, LyudmillaNedyalkova, Ryan Climie, Keith Lawson, Maria Augusta Sartori, Sabriyeh Alibai, David Tieu, Sanna Masud, Patricia Mero, Alexander Weiss, Kevin R. Brown, Matej Ušaj, Maximilian Billmann, Mahfuzur Rahman, Michael Costanzo, Chad L. Myers, Brenda Andrews, Charlie Boone, Daniel Durocher, Jason Moffat

A Pif1-dependent threshold separates DNA double-strand breaks and telomeres
Daniel Durocher, Jonathan Strecker

A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing
Marella Canny, Leo Wan, Amelie Fradet-Turcotte, Alexandre Orthwein, Nathalie Moatti, Yu-Chi Juang, Wei Zhang, Sylvie M Noordermeer, Marcus D Wilson, Andrew Vorobyov, Meagan Munro, Andreas Ernst, Michal Zimmermann, Timothy F Ng, Sachdev S Sidhu, Frank Sicheri, Daniel Durocher

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.
Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM.
Genes Dev. 2017 Feb 1;31(3):260-274. doi: 10.1101/gad.292516.116.
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Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F.
Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.
Nucleic Acids Research. 2017 Jan 25;45(2):805-817. doi: 10.1093/nar/gkw1181.
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Hustedt N, Durocher D.
The control of DNA repair by the cell cycle.
Nature Cell Biology. 2016 Dec 23;19(1):1-9. doi: 10.1038/ncb3452.
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Connor AA, Denroche RE, Jang GH, Timms L, Kalimuthu SN, Selander I, McPherson T, Wilson GW, Chan-Seng-Yue MA, Borozan I, Ferretti V, Grant RC, Lungu IM, Costello E, Greenhalf W, Palmer D, Ghaneh P, Neoptolemos JP, Buchler M, Petersen G, Thayer S, Hollingsworth MA, Sherker A, Durocher D, Dhani N, Hedley D, Serra S, Pollett A, Roehrl MH, Bavi P, Bartlett JM, Cleary S, Wilson JM, Alexandrov LB, Moore M, Wouters BG, McPherson JD, Notta F, Stein LD, Gallinger S.
Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.
JAMA Oncology. 2016 Oct 20. doi: 10.1001/jamaoncol.2016.3916.
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Goullet de Rugy T, Bashkurov M, Datti A, Betous R, Guitton-Sert L, Cazaux C, Durocher D, Hoffmann JS.
Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells.
Biology Open. 2016 Oct 15;5(10):1485-1492. doi: 10.1242/bio.018028.
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Durocher D, Pelletier L.
53BP1 Goes Back to Its p53 Roots.
Molecular Cell. 2016 Oct 6;64(1):3-4. doi: 10.1016/j.molcel.2016.09.024.
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Wan LC, Pillon MC, Thevakumaran N, Sun Y, Chakrabartty A, Guarné A, Kurinov I, Durocher D, Sicheri F.
Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.
Nucleic Acids Research. 2016 Aug 19;44(14):6971-80. doi: 10.1093/nar/gkw542.
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Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D.
The structural basis of modified nucleosome recognition by 53BP1.
Nature. 2016 Aug 4;536(7614):100-3.
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Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Côté J.
The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.
Molecular Cell. 2016 May 5;62(3):409-21. doi: 10.1016/j.molcel.2016.03.031.
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DNA damage signalling targets the kinetochore to promote chromatin mobility.
Strecker J, Gupta GD, Zhang W, Bashkurov M, Landry MC, Pelletier L, Durocher D.
Nature Cell Biology. 2016 Mar;18(3):281-90. doi: 10.1038/ncb3308.
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Tkáč J, Xu G, Adhikary H, Young JT, Gallo D, Escribano-Díaz C, Krietsch J, Orthwein A, Munro M, Sol W, Al-Hakim A, Lin ZY, Jonkers J, Borst P, Brown GW, Gingras AC, Rottenberg S, Masson JY, Durocher D.
HELB Is a Feedback Inhibitor of DNA End Resection.
Molecular Cell. 2016 Feb 4;61(3):405-18. doi: 10.1016/j.molcel.2015.12.013.
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Orthwein A, Noordermeer SM, Wilson MD, Landry S, Enchev RI, Sherker A, Munro M, Pinder J, Salsman J, Dellaire G, Xia B, Peter M, Durocher D.
A mechanism for the suppression of homologous recombination in G1 cells.
Nature. 2015 Dec 9. doi: 10.1038/nature16142.
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Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J.
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.
Cell. 2015 Dec 3;163(6):1515-26. doi: 10.1016/j.cell.2015.11.015.
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Campos EI, Smits AH, Kang YH, Landry S, Escobar TM, Nayak S, Ueberheide BM, Durocher D, Vermeulen M, Hurwitz J, Reinberg D.
Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.
Molecular Cell. 2015 Nov 19;60(4):697-709. doi: 10.1016/j.molcel.2015.08.005.
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Chung DK, Chan JN, Strecker J, Zhang W, Ebrahimi-Ardebili S, Lu T, Abraham KJ, Durocher D, Mekhail K.
Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process.
Nature Communications. 2015 Jul 24;6:7742. doi: 10.1038/ncomms8742.
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Boersma V, Moatti N, Segura-Bayona S, Peuscher MH, van der Torre J, Wevers BA, Orthwein A, Durocher D, Jacobs JJ.
MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection.
Nature. 2015 Mar 23. doi: 10.1038/nature14216.
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Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, Toro A, Lucas JL, Vuga D, Lehmann L, Durocher D, Zeng Q, Patterson JB, Sicheri F.
Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Nature Communications. 2014 Aug 28;5:4202. doi: 10.1038/ncomms5202. PMID: 25164867

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Wybenga-Groot LE, Ho CS, Sweeney FD, Ceccarelli DF, McGlade CJ, Durocher D, Sicheri F.
Structural basis of Rad53 kinase activation by dimerization and activation segment exchange.
Cell Signal. 2014 Sep;26(9):1825-36. doi: 10.1016/j.cellsig.2014.05.004

 

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Orthwein A, Fradet-Turcotte A, Noordermeer SM, Canny MD, Brun CM, Strecker J, Escribano-Diaz C, Durocher D.
Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions.
Science. 2014 Mar 20. PMID: 24652939

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Leung JW, Agarwal P, Canny MD, Gong F, Robison AD, Finkelstein IJ, Durocher D, Miller KM.
Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling.
PLoS Genet. 2014 Mar 6;10(3):e1004178. PMID: 24603765
[DOI: 10.1371/journal.pgen.1004178]

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Ramaekers CH, van den Beucken T, Bristow RG, Chiu RK, Durocher D, Wouters BG.
RNF8-Independent Lys63 Poly-Ubiquitylation Prevents Genomic Instability in Response to Replication-Associated DNA Damage.
PLoS One. 2014 Feb 28;9(2):e89997. PMID: 24587176
[DOI: 10.1371/journal.pone.0089997]

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Panier S, Durocher D.
Push back to respond better: regulatory inhibition of the DNA double-strand break response.
Nature Reviews Molecular Cell Biology. 2013 13:661-72. PMID: 24002223
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Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC, Nesvizhskii AI.
The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.
Nature Methods. 2013 10:730-6. PMID: 23921808
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Escribano-Diaz C, Durocher D.
DNA repair pathway choice–a PTIP of the hat to 53BP1.
EMBO Reports. 2013 14:665-6. PMID: 23846307
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Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CC, Huang H, Landry MC, Kitevski-Leblanc J, Noordermeer SM, Sicheri F, Durocher D.
53BP1 is a reader of the DNA-damage-induced H2A Lys15 ubiquitin mark.
Nature. 2013 Jun 12. PMID:23760478
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Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F.
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
Nucleic Acids Research. 2013 Apr 25. PMID:23620299
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Jackson SP, Durocher D.
Regulation of DNA damage responses by ubiquitin and SUMO.
Molecular Cell. 2013 Mar 7;49(5):795-807. Review. PMID:23416108
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Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkáč J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D, Durocher D.
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.
Molecular Cell. 2013 Mar 7;49(5):872-83. PMID: 23333306
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Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SS.
A strategy for modulation of enzymes in the ubiquitin system.
Science. 2013 Feb 1;339(6119):590-5. PMID: 23287719
Abstract

Panier S, Ichijima Y, Fradet-Turcotte A, Leung CC, Kaustov L, Arrowsmith CH, Durocher D.
Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.
Molecular Cell. 2012 Aug 10;47(3):383-95. PMID: 22742833
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Yang J, O’Donnell L, Durocher D, Brown GW.
RMI1 Promotes DNA Replication Fork Progression and Recovery from Replication Fork Stress.
Molecular and Cellular Biology. 2012 Aug;32(15):3054-64. PMID: 22645306
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Juang YC, Landry MC, Sanches M, Vittal V, Leung CC, Ceccarelli DF, Mateo AR, Pruneda JN, Mao DY, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, Durocher D.
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.
Molecular Cell. 2012 Feb 10;45(3):384-97. PMID: 22325355
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Al-Hakim AK, Bashkurov M, Gingras AC, Durocher D, Pelletier L.
Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.
Mol Cell Proteomics. 2012 Jun;11(6):M111.014233. PMID: 22261722
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Yeung M, Durocher D.
Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin.
DNA Repair. 2011 Dec 10;10(12):1213-22. PMID: 21982442
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Lackner DH, Durocher D, Karlseder J.
A siRNA-Based Screen for Genes Involved in Chromosome End Protection.
PLoS One. 2011;6(6):e21407. PMID: 21760879
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Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F.
An allosteric inhibitor of the human cdc34 ubiquitin-conjugating enzyme.
Cell. 2011 Jun 24;145(7):1075-87. PMID: 21683433
Abstract

 

Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG.
MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.
Cell Cycle. 2011 Jul 1;10(13):2218-32. PMID: 21623170
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Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, Stewart GS, Sanchez O, Hande MP, Durocher D, Hakem A, Hakem R.
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
PLoS Genetics. 2011 Apr;7(4):e1001381. PMID: 21552324
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Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, Liu Z, Malyankar UM, Chiovitti D, Canny M, Durocher D, Sicheri F, Patterson JB.
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease.
Journal of Biological Chemistry. 2011 Apr 8;286(14):12743-55. PMID: 21303903
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Ito E, Yue S, Moriyama EH, Hui AB, Kim I, Shi W, Alajez NM, Bhogal N, Li G, Datti A, Schimmer AD, Wilson BC, Liu PP, Durocher D, Neel BG, O’Sullivan B, Cummings B, Bristow R, Wrana J, Liu FF.
Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer.
Science Translational Medicine. 2011 Jan 26;3(67):67ra7. PMID: 21270338
Abstract

Al-Hakim A, Escribano-Diaz C, Landry MC, O’Donnell L, Panier S, Szilard RK, Durocher D.
The ubiquitous role of ubiquitin in the DNA damage response.
DNA Repair (Amst). 2010 Dec 10;9(12):1229-40. Review.
PMID: 21056014
Abstract

 

O’Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D.
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.
Molecular Cell. 2010 Nov 24;40(4):619-31. PMID:21055983
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Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O’Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D.
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
Nature. 2010 Aug 19;466(7309):941-6. PMID: 20725033
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O’Donnell L, Durocher D
DNA Repair Has a New FAN1 Club.
Molecular Cell 2010 39(2):167-169. PMID: 20670886
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Li L, Halaby MJ, Hakem A, Cardoso R, El Ghamrasni S, Harding S, Chan N, Bristow R, Sanchez O, Durocher D, Hakem R.
Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.
Journal of Experimental Medicine. 2010 207(5):983-97. PMID: 20385750
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Zhang W, Durocher D.
De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks.
Genes & Development. 2010 24(5):502-15. PMID: 20194442
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Szilard RK, Jacques PE, Laramée L, Cheng B, Galicia S, Bataille AR, Yeung M, Mendez M, Bergeron M, Robert F, Durocher D.
Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.
Nature Structural & Molecular Biology. 2010 17(3):299-305. PMID: 20139982
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Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski DP.
CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation.
PLoS Biology. 2010 Jan 26;8(1):e1000286. PMID: 20126259
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Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A.
The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.
Proc Natl Acad Sci U S A. 2010 107(2):809-14. PMID: 20080757
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Lilley CE, Chaurushiya MS, Boutell C, Landry S, Suh J, Panier S, Everett RD, Stewart GS, Durocher D, Weitzman MD.
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses.
EMBO Journal. 2010 Mar 3;29(5):943-55. Epub 2010 Jan 14.PMID: 20075863
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Panier S, Durocher D.
Regulatory ubiquitylation in response to DNA double-strand breaks.
DNA Repair. 2009 Apr 5;8(4):436-43.
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Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C.
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.
Cell. 2009 Feb 6;136(3):435-46.
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Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro A, Pelletier L, Taubenheim N, Durandy A, Byrd PJ, Stankovic T, Taylor AM, Durocher D.
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.
Cell. 2009 Feb 6;136(3):420-34.
Abstract

Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F.
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol Cell. 2008 Oct 24;32(2):259-75.

 

Dixon SJ, Fedyshyn Y, Koh JL, Prasad TS, Chahwan C, Chua G, Toufighi K, Baryshnikova A, Hayles J, Hoe KL, Kim DU, Park HO, Myers CL, Pandey A, Durocher D, Andrews BJ, Boone C.
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16653-8.

 

Addinall SG, Downey M, Yu M, Zubko M, Dewar J, Leake A, Hallinan J, Shaw O, James K, Wilkinson DJ, Wipat A, Durocher D, Lydall D.
A Genome-wide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae.
Genetics 2008 Oct 9. [Epub ahead of print]

 

Nakada S, Chen GI, Gingras AC, Durocher D.
PP4 is a gammaH2AX phosphatase required for recovery from the DNA damage checkpoint.
EMBO Rep. 2008 Oct;9(10):1019-26. Epub 2008 Aug 29.

 

Yeung M, Durocher D.
Engineering a DNA damage response without DNA damage.
Genome Biol. 2008;9(7):227.

 

Zhang W, Durocher D.
Dun1 counts on Rad53 to be turned on.
Mol Cell. 2008 Jul 11;31(1):1-2.

 

Fu Y, Zhu Y, Zhang K, Yeung M, Durocher D, Xiao W.
Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.
Cell. 2008 May 16;133(4):601-11.

 

Macrae CJ, McCulloch RD, Ylanko J, Durocher D, Koch CA.
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation.
DNA Repair (Amst). 2008 Feb 1;7(2):292-302.

Kolas NK, Chapman JR , Nakada S, Ylanko Y, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D.
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase.
Science [DOI: 10.1126/science.1150034]

Abstract
Science Reprint

 

Kanellis P, Gagliardi M, Banath JP, Szilard RK, Nakada S, Galicia S, Sweeney FD, Cabelof DC, Olive PL, Durocher D.
A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions.
PLoS Genet. 2007 Aug 10;3(8):e134.
PubMed abstract
Reprint

Woolstencroft RN, Beilharz TH, Cook MA, Preiss T, Durocher D, Tyers M.
Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length.
J Cell Sci. 2006 Dec 15;119(Pt 24):5178-92.
PubMed abstract

 

Szilard RK, Durocher D.
Telomere protection: an act of God.
Curr Biol. 2006 Jul 25;16(14):R544-6.
PubMed abstract

 

Downey M, Durocher D.
GammaH2AX as a checkpoint maintenance signal.
Cell Cycle. 2006 Jul;5(13):1376-81. Epub 2006 Jul 1.
PubMed abstract

 

Blake D, Luke B, Kanellis P, Jorgensen P, Goh T, Penfold S, Breitkreutz BJ, Durocher D, Peter M, Tyers M.
The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae.
Genetics. 2006 Jun 4.
PubMed abstract | Text on genetics.org

 

Kolas NK, Durocher D.
DNA repair: DNA polymerase zeta and Rev1 break in.
Curr Biol. 2006 Apr 18;16(8):R296-9.
PubMed abstract

 

Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D.
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.
Cell. 2006 Mar 24;124(6):1155-68.
PubMed abstract

 

Downey M, Durocher D.
Chromatin and DNA repair: the benefits of relaxation.
Nat Cell Biol. 2006 Jan;8(1):9-10.

 

Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ.
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.
Nature. 2006 Jan 26;439(7075):497-501. Epub 2005 Nov 20.
PubMed abstract

Sweeney FD, Yang F, Chi A, Shabanowitz J, Hunt DF, Durocher D.
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation.
Curr Biol. 2005 Aug 9;15(15):1364-75.
PubMed abstract

 

Tyers M, Brown E, Andrews DW, Bergeron JJ, Boone C, Bremner R, Bussey HA, Cross JC, Davies JE, Desjardins M, Dick JE, Dumont DJ, Durocher D, Ellison MJ, Golding GB, Gray MW, Harrington LA, Hieter PA, Johnston G, Kelvin DJ, McCarry BE, Michnick SW, Ouellette F, Pearlman RE, Penn LJ, Pelletier J, Rachubinski RA, Rennie PS, Rotin D, Rottapel R, Sadowski I, Sicheri F, Siminovitch L, Sonenberg N, Siu KW, Tremblay ML, Winegarden N, Wozniak RW, Wright GD, Woodgett JR.
Problems with co-funding in Canada.
Science. 2005 Jun 24;308(5730):1867.

 

Bernstein NK, Williams RS, Rakovszky ML, Cui D, Green R, Karimi-Busheri F, Mani RS, Galicia S, Koch CA, Cass CE, Durocher D, Weinfeld M, Glover JN.
The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase.
Mol Cell. 2005 Mar 4;17(5):657-70.
PubMed abstract

Koch CA, Agyei R, Galicia S, Metalnikov P, O’Donnell P, Starostine A, Weinfeld M, Durocher D.
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.
EMBO J. 2004 Oct 1;23(19):3874-85. Epub 2004 Sep 23.
PubMed abstract | Text on PubMed Central
Kanellis P, Agyei R, Durocher D.
Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability.
Curr Biol. 2003 Sep 16;13(18):1583-95.
PubMed abstract

 

Durocher D, Smerdon SJ, Yaffe MB, Jackson SP.
The FHA domain in DNA repair and checkpoint signaling.
Cold Spring Harb Symp Quant Biol. 2000;65:423-31. Review.

 

Durocher D.
Bacterial signal transduction: a FHAscinating glimpse at the origins of phospho-dependent signal transduction.
Trends Microbiol. 2003 Feb;11(2):67-8.

Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D, Yaffe MB, Jackson SP, Smerdon SJ.
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.
Mol Cell. 2002 May;9(5):1045-54.
PubMed abstract

 

Durocher D, Jackson SP. Related Articles, Links Abstract
The FHA domain.
FEBS Lett. 2002 Feb 20;513(1):58-66. Review.
PubMed abstract

 

Ho Y, Gruhler A, Heilbut A, Bader GD, Moore L, Adams SL, Millar A, Taylor P, Bennett K, Boutilier K, Yang L, Wolting C, Donaldson I, Schandorff S, Shewnarane J, Vo M, Taggart J, Goudreault M, Muskat B, Alfarano C, Dewar D, Lin Z, Michalickova K, Willems AR, Sassi H, Nielsen PA, Rasmussen KJ, Andersen JR, Johansen LE, Hansen LH, Jespersen H, Podtelejnikov A, Nielsen E, Crawford J, Poulsen V, Sorensen BD, Matthiesen J, Hendrickson RC, Gleeson F, Pawson T, Moran MF, Durocher D, Mann M, Hogue CW, Figeys D, Tyers M.
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
Nature. 2002 Jan 10; 415(6868):180-3
PubMed abstract

Durocher D and Jackson SP.
DNA-PK, ATM and ATR, variations on a theme?
Curr Opin Cell Biol . 2001 Apr 13 (2):225-31. Review.
PubMed abstract
Durocher D., Yaffe MB and Jackson SP.
Regulation of DNA damage signalling by FHA domains.
Cold Spring Harbor Symposia on Quantitative Biology (2000) Review.

 

Durocher D, Taylor IA, Sarbassova D, Haire LH, Westcott SL, Jackson SP, Smerdon SJ and Yaffe MB.
The molecular basis of FHA domain: phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
Molecular Cell. 2000, 6:1169-1182
PubMed abstract | Text on molecule.org

Durocher D, Henckel J, Fersht A, Jackson SP.
The FHA domain is a modular phosphopeptide recognition motif.
Molecular Cell. 1999, 4:387-394
PubMed abstract | Text on molecule.org
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