In Memoriam
Silvia Emma Rossi
We are deeply saddened by the passing of our dear friend and colleague Dr. Silvia Emma Rossi on June 3rd 2021 from leukemia. Silvia was first a wonderful human being that brought so much joy to everyone who knew her. She had an irrepressible smile, had infectious kindness and was dedicated friend and daughter. She was also a very talented scientist, having trained at IFOM in Milan with Marco Foiani and Michele Giannattasio where she studied the role of helicases and nucleases in the response to DNA replication stress [1,2]. In our lab, Silvia undertook a foundational synthetic lethal screen in BRCA2-/- cells that led us to work on APEX2 [3] and CIP2A [4,5] that we characterized, in collaboration with Silvia, as promising targets against BRCA-deficient tumors. She was also very collaborative and contributed to work that is published [6] or that remains in preparation. The entire Durocher lab offers our condolences to her family and friends. We endeavor to celebrate her life and achievements.
You can consult Silvia’s publications below:
1. Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress
Silvia Emma Rossi, Arta Ajazi, Walter Carotenuto, Marco Foiani, Michele Giannattasio
PMID: 26411679 PMCID: PMC4597105 DOI: 10.1016/j.celrep.2015.08.073
Abstract
Full Text
2. Dna2 processes behind the fork long ssDNA flaps generated by Pif1 and replication-dependent strand displacement
Silvia Emma Rossi, Marco Foiani, Michele Giannattasio
PMID: 30446656 PMCID: PMC6240037 DOI: 10.1038/s41467-018-07378-5
Abstract
Full Text
3. Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease
Alejandro Álvarez-Quilón, Jessica L. Wojtaszek, Marie-Claude Mathieu, Tejas Patel, C. Denise Appel, Nicole Hustedt, Silvia Emma Rossi, Bret D Wallace, Dheva Setiaputra, Salomé Adam, Yota Ohashi, Henrique Melo, Tiffany Cho, Christian Gervais, Ivan M. Muñoz, Eric Grazzini, Jordan T.F. Young, John Rouse, Michael Zinda, R. Scott Williams, Daniel Durocher
PMID: 32516598 PMCID: PMC7340272 DOI: 10.1016/j.molcel.2020.05.021
Abstract
Full Text
4. CIP2A is a prime synthetic-lethal target for BRCA-mutated cancers
Salomé Adam, Silvia Emma Rossi, Nathalie Moatti, Mara De Marco Zompit, Timothy F. Ng, Alejandro Álvarez-Quilón, Jessica Desjardins, Vivek Bhaskaran, Giovanni Martino, Dheva Setiaputra, Sylvie M. Noordermeer, Toshiro K. Ohsumi, Nicole Hustedt, Rachel K. Szilard, Natasha Chaudhary, Meagan Munro, Artur Veloso, Henrique Melo, Shou Yun Yin, Robert Papp, Jordan T.F. Young, Michael Zinda, Manuel Stucki, Daniel Durocher
doi: https://doi.org/10.1101/2021.02.08.430060
Abstract
Full Text
5. The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis
Mara De Marco Zompit, Clémence Mooser, Salomé Adam, Silvia Emma Rossi, Alain Jeanrenaud, Pia-Amata Leimbacher, Daniel Fink, Daniel Durocher, Manuel Stucki
Abstract
Full Text
6. A Genetic Map of the Response to DNA Damage in Human Cells
Michele Olivieri, Tiffany Cho, Alejandro Álvarez-Quilón, Kejiao Li, Matthew J. Schellenberg, Michal Zimmermann, Nicole Hustedt, Silvia Emma Rossi, Salomé Adam, Henrique Melo, Anne Margriet Heijink, Guillermo Sastre-Moreno, Nathalie Moatti, Rachel K Szilard, Andrea McEwan, Alexanda K Ling, Almudena Serrano-Benitez, Tajinder Ubhi, Sumin Feng, Judy Pawling, Irene Delgado-Sainz, Michael W. Ferguson, James W. Dennis, Grant W. Brown, Felipe Cortés-Ledesma, R. Scott Williams, Alberto Martin, Dongyi Xu, Daniel Durocher
Abstract
Full Text