Publications
Sumin Feng, Kaiwen Liu, Jinfeng Shang, Lisa Hoeg, William Yang, Sabrina Roy, Jordan TF Young, Wei Wu, Dongyi Xu, Daniel Durocher
Profound synthetic lethality between SMARCAL1 and FANCM
doi: https://doi.org/10.1101/2024.02.27.582393
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YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Ahmad Malik, Nicolas S. Gonzalez-Foutel, Carmen Florencia Suarez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N. Al-Zahrani, Zhen Yuan Lin, Ricky Tsai, Varda Rotter, Patricia Ashton-Prolla, Lucia B. Chemes, Jason Moffat, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
Mol Syst Biol (2024)20: 719 – 740 . https://doi.org/10.1038/s44320-024-00032-x
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, , , , , , , , , , , , , , , C21ORF2 association with the NEK1 kinase mutated in human in diseases
Chérine Sifri, Lisa Hoeg, Daniel Durocher, Dheva Setiaputra
An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3–RIF1 interaction critical for shieldin activity
EMBO rep(2023)24: e56834. https://doi.org/10.15252/embr.202356834
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Yichao Zhao, Daniel Tabet, Diana Rubio Contreras, Arne Nedergaard Kousholt, Jochen Weile, Henrique Melo, Lisa Hoeg, Atina G. Coté, Zhen-Yuan Lin, Dheva Setiaputra, Jos Jonkers, Anne-Claude Gingras, Fernando Gómez Herreros, Frederick P. Roth, Daniel Durocher
Genome-scale mapping of DNA damage suppressors identifies GNB1L as essential for ATM and ATR biogenesis
Molecular Cell, Volume 83, Issue 15, 2792 – 2809.e9 . doi: 10.1016/j.molcel.2023.06.025
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De Marco Zompit M, Esteban MT, Mooser C, Adam S, Rossi SE, Jeanrenaud A, Leimbacher PA, Fink D, Shorrocks AK, Blackford AN, Durocher D, Stucki M.
The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis
Nature Communications. 2022 Jul 16;13(1):4143. doi: 10.1038/s41467-022-31865-5.PMID: 35842428
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Tkach JM, Philip R, Sharma A, Strecker J, Durocher D, Pelletier L.
Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number
Elife. 2022 Jun 27;11:e73944. doi: 10.7554/eLife.73944. PMID: 35758262
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Gallo D, Young JFT, Fourtounis J, Martino G, Álvarez-Quilón A, Bernier C, Duffy NM, Papp R, Roulston A, Stocco R, Szychowski J, Veloso A, Alam H, Baruah PS, Fortin AB, Bowlan J, Chaudhary N, Desjardins J, Dietrich E, Fournier S, Fugère-Desjardins C, Goulet de Rugy T, Leclaire M-E, Liu B, Bhaskaran V, Mamane Y, Melo H, Nicolas O, Singhania A, Szilard RK, Tkáč J, Yin SY, Morris SJ, Zinda M, Marshall CG, Durocher D.
CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition
Nature 2022. 604(7907):749-756. PMID: 35444283
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Setiaputra D, Escribano-Diaz C, Reinert JK, Sadana P, Zong D, Callen E, Sifri C, Seebacher J, Nussenzweig A, Thomä NH, Durocher D.
RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1
Molecular Cell 2022. 82(7):1359-1371. (PMID: 35216668)
Abstract
Adam S, Rossi SE, Moatti N, De Marco Zompit M, Xue Y, Ng TF, Álvarez-Quilón A, Desjardins J, Bhaskaran V, Martino G, Setiaputra D, Noordermeer SM, Ohsumi TK, Hustedt N, Szilard RK, Chaudhary N, Munro M, Veloso A, Melo H, Yin SY, Papp R, Young JTF, Zinda M, Stucki M, Durocher D.
The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer
Nature Cancer. 2021 Dec;2(12):1357-1371. (PMID: 35121901)
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Feng Y, Li C, Stewart JA, Barbulescu P, Desivo NS, Álvarez-Quilón A, Pezo RC, Perera MLW, Chan K, Yan Tong AH, Mohamad-Ramshan R, Berru M, Nakib D, Li G, Ali Kardar G, Carlyle JR, Moffat J, Durocher D, Di Noia JM, Bhagwat AS, Martin A.
FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation
Nature 2021. 600(7888):324-328. (PMID: 34819670)
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Sherker A, Chaudhary N, Adam S, Noordermeer SM, Fradet-Turcotte, Durocher D.
Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites
EMBO Reports 2021. 22(12):e53679. (PMID: 34726323)
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Anderson ND, Babichev Y, Fuligni F, Comitani F, Layeghifard M, Venier RE, Dentro S, Maheshwari A, Guram S, Wunker C, Thompson JD, Yuki K, Hou H, Zatzman M, Light N, Bernadini MQ, Wunder JS, Andrulis IL, Ferguson P, Razak, ARA, Swallow CJ, Dowling JJ, Al-Awar RS, Marcellus R, Rouzbahman M, Gerstung M, Durocher D, Alexandrov LB, Dickson BC, Gladdy RA, Shlien A.
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
Nature Communications 2021. 12(1):4496. (PMID: 34301934)
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Olivieri M, Durocher D.
Genome-scale chemogenomic CRISPR screens in human cells using the TKOv3 library
STAR Protocols 2021. 2(1):100321. (PMID: 33598657)
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Beenstock J, Ona SM, Porat J, Orlicky S, Wan LCK, Ceccareli DF, Maisonneuve P, Szilard R, Yin Z, Setiaputra D, Mao DYL, Khan M, Raval S, Schriemer DC, Bayfield MA, Durocher D, Sicheri F.
A substrate binding model for the KEOPS tRNA modifying complex
Nature Communications 2020. 11(1):6233. (PMID: 33277478)
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Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygordosky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras A-C, Al-Awar R, Therrien M, Sicheri F.
Functional characterization of a PROTAC directed against BRAF mutant V600E
Nature Chemical Biology 2020. 16(11):1170-1178. (PMID: 32778845)
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, , , , , , , , , , , , , , , , , , Sumin Feng, Judy Pawling, , , James W. Dennis, , , , , ,
Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8.PMID: 32516598
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SHLD2 promotes class switch recombination by preventing inactivating deletions within the Igh locus.
EMBO Rep. 2020 Jun 17:e49823. doi: 10.15252/embr.201949823. Online ahead of print.PMID: 32558186
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A consensus set of genetic vulnerabilities to ATR inhibition
Open Biol. 2019 Sep 27;9(9):190156. doi: 10.1098/rsob.190156. Epub 2019 Sep 11.
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Hustedt N, Saito Y, Zimmermann M, Álvarez-Quilón A, Setiaputra D, Adam S, McEwan A, Yuan JY, Olivieri M, Zhao Y, Kanemaki MT, Jurisicova A, Durocher D.
Control of homologous recombination by the HROB-MCM8-MCM9 pathway.
Genes Dev. 2019 Aug 29. doi: 10.1101/gad.329508.119.
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Colic M, Wang G, Zimmermann M, Mascall K, McLaughlin M, Bertolet L, Lenoir WF, Moffat J, Angers S, Durocher D, Hart T.
Identifying chemogenetic interactions from CRISPR screens with drugZ.
Genome Med. 2019 Aug 22;11(1):52. doi: 10.1186/s13073-019-0665-3.
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Setiaputra D, Durocher D.
Shieldin – the protector of DNA ends.
EMBO Rep. 2019 Apr 4. pii: e47560. doi: 10.15252/embr.201847560.
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Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A.
BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.
Mol Cell. 2019 Mar 21;73(6):1267-1281.e7. doi: 10.1016/j.molcel.2018.12.010. Epub 2019 Jan 28.
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Noordermeer SM, Adam S, Setiaputra D, Barazas M, Pettitt SJ, Ling AK, Olivieri M, Álvarez-Quilón A, Moatti N, Zimmermann M, Annunziato S, Krastev DB, Song F, Brandsma I, Frankum J, Brough R, Sherker A, Landry S, Szilard RK, Munro MM, McEwan A, Goullet de Rugy T, Lin ZY, Hart T, Moffat J, Gingras AC, Martin A, van Attikum H, Jonkers J, Lord CJ, Rottenberg S, Durocher D.
The shieldin complex mediates 53BP1-dependent DNA repair.
Nature. 2018 Aug;560(7716):117-121. doi: 10.1038/s41586-018-0340-7. Epub 2018 Jul 18.
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Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, Bianchi A, Zimmermann M, Durocher D, de Lange T.
53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.
Nature. 2018 Aug;560(7716):112-116. doi: 10.1038/s41586-018-0324-7. Epub 2018 Jul 18.
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Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaitė Ž, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, Chandrashekhar M, Angers S, Moffat J, Brunton VG, Hart T, de Bono J, Stankovic T, Jackson AP, Durocher D.
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.
Nature.2018 Jul;559(7713):285-289. doi: 10.1038/s41586-018-0291-z. Epub 2018 Jul 4.
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Díaz-Mejía JJ, Celaj A, Mellor JC, Coté A, Balint A, Ho B, Bansal P, Shaeri F, Gebbia M, Weile J, Verby M, Karkhanina A, Zhang Y, Wong C, Rich J, Prendergast D, Gupta G, Öztürk S, Durocher D, Brown GW, Roth FP.
Mapping DNA damage-dependent genetic interactions in yeast via party mating and barcode fusion genetics.
Mol Syst Biol. 2018 May 28;14(5):e7985. doi: 10.15252/msb.20177985.
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Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D.
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.
Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27.
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Batenburg NL, Walker JR, Noordermeer SM, Moatti N, Durocher D, Zhu XD.
ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.
Nat Commun. 2017 Dec 4;8(1):1921. doi: 10.1038/s41467-017-02114-x.
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Wilson MD, Durocher D.
Reading chromatin signatures after DNA double-strand breaks.
Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731). pii: 20160280. doi: 10.1098/rstb.2016.0280. Review.
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Strecker J, Stinus S, Caballero MP, Szilard RK, Chang M, Durocher D.
A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres.
Elife. 2017 Aug 3;6. pii: e23783. doi: 10.7554/eLife.23783.
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Dawson N, Burton MC, Hull B, Beliles G, Pritchard I, Trautman C, Ferry L, Doyon A, Colby R, Chuu A, Kung ST, Khang T, Durocher D, Buras M, Kosiorek H, Agrwal N, Sen A, Goss D, Geyer H.
Relation of Telemetry Use and Mortality Risk, Hospital Length of Stay, and Readmission Rates in Patients With Respiratory Illness.
Am J Cardiol. 2017 Oct 15;120(8):1416-1420. doi: 10.1016/j.amjcard.2017.07.029. Epub 2017 Jul 25.
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Hart T, Tong AHY, Chan K, Van Leeuwen J, Seetharaman A, Aregger M, Chandrashekhar M, Hustedt N, Seth S, Noonan A, Habsid A, Sizova O, Nedyalkova L, Climie R, Tworzyanski L, Lawson K, Sartori MA, Alibeh S, Tieu D, Masud S, Mero P, Weiss A, Brown KR, Usaj M, Billmann M, Rahman M, Constanzo M, Myers CL, Andrews BJ, Boone C, Durocher D, Moffat J.
Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.
G3 (Bethesda). 2017 Aug 7;7(8):2719-2727. doi: 10.1534/g3.117.041277.
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Kitevski-LeBlanc J, Fradet-Turcotte A, Kukic P, Wilson MD, Portella G, Yuwen T, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith CH, Rubinstein JL, Vendruscolo M, Durocher D, Kay LE.
The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.
Elife. 2017 Apr 13;6. pii: e23872. doi: 10.7554/eLife.23872.
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Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM.
ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.
Genes Dev. 2017 Feb 1;31(3):260-274. doi: 10.1101/gad.292516.116.
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Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F.
Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.
Nucleic Acids Research. 2017 Jan 25;45(2):805-817. doi: 10.1093/nar/gkw1181.
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The control of DNA repair by the cell cycle.
Nature Cell Biology. 2016 Dec 23;19(1):1-9. doi: 10.1038/ncb3452.
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Connor AA, Denroche RE, Jang GH, Timms L, Kalimuthu SN, Selander I, McPherson T, Wilson GW, Chan-Seng-Yue MA, Borozan I, Ferretti V, Grant RC, Lungu IM, Costello E, Greenhalf W, Palmer D, Ghaneh P, Neoptolemos JP, Buchler M, Petersen G, Thayer S, Hollingsworth MA, Sherker A, Durocher D, Dhani N, Hedley D, Serra S, Pollett A, Roehrl MH, Bavi P, Bartlett JM, Cleary S, Wilson JM, Alexandrov LB, Moore M, Wouters BG, McPherson JD, Notta F, Stein LD, Gallinger S.
Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.
JAMA Oncology. 2016 Oct 20. doi: 10.1001/jamaoncol.2016.3916.
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Goullet de Rugy T, Bashkurov M, Datti A, Betous R, Guitton-Sert L, Cazaux C, Durocher D, Hoffmann JS.
Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells.
Biology Open. 2016 Oct 15;5(10):1485-1492. doi: 10.1242/bio.018028.
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Durocher D, Pelletier L.
53BP1 Goes Back to Its p53 Roots.
Molecular Cell. 2016 Oct 6;64(1):3-4. doi: 10.1016/j.molcel.2016.09.024.
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Wan LC, Pillon MC, Thevakumaran N, Sun Y, Chakrabartty A, Guarné A, Kurinov I, Durocher D, Sicheri F.
Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.
Nucleic Acids Research. 2016 Aug 19;44(14):6971-80. doi: 10.1093/nar/gkw542.
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Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D.
The structural basis of modified nucleosome recognition by 53BP1.
Nature. 2016 Aug 4;536(7614):100-3.
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Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Côté J.
The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.
Molecular Cell. 2016 May 5;62(3):409-21. doi: 10.1016/j.molcel.2016.03.031.
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DNA damage signalling targets the kinetochore to promote chromatin mobility.
Strecker J, Gupta GD, Zhang W, Bashkurov M, Landry MC, Pelletier L, Durocher D.
Nature Cell Biology. 2016 Mar;18(3):281-90. doi: 10.1038/ncb3308.
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Tkáč J, Xu G, Adhikary H, Young JT, Gallo D, Escribano-Díaz C, Krietsch J, Orthwein A, Munro M, Sol W, Al-Hakim A, Lin ZY, Jonkers J, Borst P, Brown GW, Gingras AC, Rottenberg S, Masson JY, Durocher D.
HELB Is a Feedback Inhibitor of DNA End Resection.
Molecular Cell. 2016 Feb 4;61(3):405-18. doi: 10.1016/j.molcel.2015.12.013.
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Orthwein A, Noordermeer SM, Wilson MD, Landry S, Enchev RI, Sherker A, Munro M, Pinder J, Salsman J, Dellaire G, Xia B, Peter M, Durocher D.
A mechanism for the suppression of homologous recombination in G1 cells.
Nature. 2015 Dec 9. doi: 10.1038/nature16142.
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Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J.
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.
Cell. 2015 Dec 3;163(6):1515-26. doi: 10.1016/j.cell.2015.11.015.
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Campos EI, Smits AH, Kang YH, Landry S, Escobar TM, Nayak S, Ueberheide BM, Durocher D, Vermeulen M, Hurwitz J, Reinberg D.
Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.
Molecular Cell. 2015 Nov 19;60(4):697-709. doi: 10.1016/j.molcel.2015.08.005.
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Chung DK, Chan JN, Strecker J, Zhang W, Ebrahimi-Ardebili S, Lu T, Abraham KJ, Durocher D, Mekhail K.
Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process.
Nature Communications. 2015 Jul 24;6:7742. doi: 10.1038/ncomms8742.
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Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, Toro A, Lucas JL, Vuga D, Lehmann L, Durocher D, Zeng Q, Patterson JB, Sicheri F.
Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Nature Communications. 2014 Aug 28;5:4202. doi: 10.1038/ncomms5202. PMID: 25164867
Wybenga-Groot LE, Ho CS, Sweeney FD, Ceccarelli DF, McGlade CJ, Durocher D, Sicheri F.
Structural basis of Rad53 kinase activation by dimerization and activation segment exchange.
Cell Signal. 2014 Sep;26(9):1825-36. doi: 10.1016/j.cellsig.2014.05.004
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Orthwein A, Fradet-Turcotte A, Noordermeer SM, Canny MD, Brun CM, Strecker J, Escribano-Diaz C, Durocher D.
Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions.
Science. 2014 Mar 20. PMID: 24652939
Leung JW, Agarwal P, Canny MD, Gong F, Robison AD, Finkelstein IJ, Durocher D, Miller KM.
Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling.
PLoS Genet. 2014 Mar 6;10(3):e1004178. PMID: 24603765
[DOI: 10.1371/journal.pgen.1004178]
Ramaekers CH, van den Beucken T, Bristow RG, Chiu RK, Durocher D, Wouters BG.
RNF8-Independent Lys63 Poly-Ubiquitylation Prevents Genomic Instability in Response to Replication-Associated DNA Damage.
PLoS One. 2014 Feb 28;9(2):e89997. PMID: 24587176
[DOI: 10.1371/journal.pone.0089997]
Panier S, Durocher D.
Push back to respond better: regulatory inhibition of the DNA double-strand break response.
Nature Reviews Molecular Cell Biology. 2013 13:661-72. PMID: 24002223
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Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC, Nesvizhskii AI.
The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.
Nature Methods. 2013 10:730-6. PMID: 23921808
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Escribano-Diaz C, Durocher D.
DNA repair pathway choice–a PTIP of the hat to 53BP1.
EMBO Reports. 2013 14:665-6. PMID: 23846307
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Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CC, Huang H, Landry MC, Kitevski-Leblanc J, Noordermeer SM, Sicheri F, Durocher D.
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.
Nature. 2013 Jun 12. PMID:23760478
Abstract
Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F.
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
Nucleic Acids Research. 2013 Apr 25. PMID:23620299
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Jackson SP, Durocher D.
Regulation of DNA damage responses by ubiquitin and SUMO.
Molecular Cell. 2013 Mar 7;49(5):795-807. Review. PMID:23416108
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Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkáč J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D, Durocher D.
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.
Molecular Cell. 2013 Mar 7;49(5):872-83. PMID: 23333306
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Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SS.
A strategy for modulation of enzymes in the ubiquitin system.
Science. 2013 Feb 1;339(6119):590-5. PMID: 23287719
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Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.
Molecular Cell. 2012 Aug 10;47(3):383-95. PMID: 22742833
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Yang J, O’Donnell L, Durocher D, Brown GW.
RMI1 Promotes DNA Replication Fork Progression and Recovery from Replication Fork Stress.
Molecular and Cellular Biology. 2012 Aug;32(15):3054-64. PMID: 22645306
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Juang YC, Landry MC, Sanches M, Vittal V, Leung CC, Ceccarelli DF, Mateo AR, Pruneda JN, Mao DY, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, Durocher D.
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.
Molecular Cell. 2012 Feb 10;45(3):384-97. PMID: 22325355
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Al-Hakim AK, Bashkurov M, Gingras AC, Durocher D, Pelletier L.
Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.
Mol Cell Proteomics. 2012 Jun;11(6):M111.014233. PMID: 22261722
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Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin.
DNA Repair. 2011 Dec 10;10(12):1213-22. PMID: 21982442
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Lackner DH, Durocher D, Karlseder J.
A siRNA-Based Screen for Genes Involved in Chromosome End Protection.
PLoS One. 2011;6(6):e21407. PMID: 21760879
Abstract
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Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F.
An allosteric inhibitor of the human cdc34 ubiquitin-conjugating enzyme.
Cell. 2011 Jun 24;145(7):1075-87. PMID: 21683433
Abstract
Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG.
MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.
Cell Cycle. 2011 Jul 1;10(13):2218-32. PMID: 21623170
Abstract
Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, Stewart GS, Sanchez O, Hande MP, Durocher D, Hakem A, Hakem R.
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
PLoS Genetics. 2011 Apr;7(4):e1001381. PMID: 21552324
Abstract
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Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, Liu Z, Malyankar UM, Chiovitti D, Canny M, Durocher D, Sicheri F, Patterson JB.
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease.
Journal of Biological Chemistry. 2011 Apr 8;286(14):12743-55. PMID: 21303903
Abstract
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Ito E, Yue S, Moriyama EH, Hui AB, Kim I, Shi W, Alajez NM, Bhogal N, Li G, Datti A, Schimmer AD, Wilson BC, Liu PP, Durocher D, Neel BG, O’Sullivan B, Cummings B, Bristow R, Wrana J, Liu FF.
Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer.
Science Translational Medicine. 2011 Jan 26;3(67):67ra7. PMID: 21270338
Abstract
The ubiquitous role of ubiquitin in the DNA damage response.
DNA Repair (Amst). 2010 Dec 10;9(12):1229-40. Review.
PMID: 21056014
Abstract
O’Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D.
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.
Molecular Cell. 2010 Nov 24;40(4):619-31. PMID:21055983
Abstract
Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O’Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D.
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
Nature. 2010 Aug 19;466(7309):941-6. PMID: 20725033
Abstract
O’Donnell L, Durocher D
DNA Repair Has a New FAN1 Club.
Molecular Cell 2010 39(2):167-169. PMID: 20670886
Abstract
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Li L, Halaby MJ, Hakem A, Cardoso R, El Ghamrasni S, Harding S, Chan N, Bristow R, Sanchez O, Durocher D, Hakem R.
Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.
Journal of Experimental Medicine. 2010 207(5):983-97. PMID: 20385750
Abstract
Zhang W, Durocher D.
De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks.
Genes & Development. 2010 24(5):502-15. PMID: 20194442
Abstract
Szilard RK, Jacques PE, Laramée L, Cheng B, Galicia S, Bataille AR, Yeung M, Mendez M, Bergeron M, Robert F, Durocher D.
Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.
Nature Structural & Molecular Biology. 2010 17(3):299-305. PMID: 20139982
Abstract
Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski DP.
CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation.
PLoS Biology. 2010 Jan 26;8(1):e1000286. PMID: 20126259
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Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A.
The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.
Proc Natl Acad Sci U S A. 2010 107(2):809-14. PMID: 20080757
Full Text
Lilley CE, Chaurushiya MS, Boutell C, Landry S, Suh J, Panier S, Everett RD, Stewart GS, Durocher D, Weitzman MD.
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses.
EMBO Journal. 2010 Mar 3;29(5):943-55. Epub 2010 Jan 14.PMID: 20075863
Abstract
Regulatory ubiquitylation in response to DNA double-strand breaks.
DNA Repair. 2009 Apr 5;8(4):436-43.
Abstract
Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C.
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.
Cell. 2009 Feb 6;136(3):435-46.
Abstract
Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro A, Pelletier L, Taubenheim N, Durandy A, Byrd PJ, Stankovic T, Taylor AM, Durocher D.
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.
Cell. 2009 Feb 6;136(3):420-34.
Abstract
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol Cell. 2008 Oct 24;32(2):259-75.
Dixon SJ, Fedyshyn Y, Koh JL, Prasad TS, Chahwan C, Chua G, Toufighi K, Baryshnikova A, Hayles J, Hoe KL, Kim DU, Park HO, Myers CL, Pandey A, Durocher D, Andrews BJ, Boone C.
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16653-8.
Addinall SG, Downey M, Yu M, Zubko M, Dewar J, Leake A, Hallinan J, Shaw O, James K, Wilkinson DJ, Wipat A, Durocher D, Lydall D.
A Genome-wide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae.
Genetics 2008 Oct 9. [Epub ahead of print]
Nakada S, Chen GI, Gingras AC, Durocher D.
PP4 is a gammaH2AX phosphatase required for recovery from the DNA damage checkpoint.
EMBO Rep. 2008 Oct;9(10):1019-26. Epub 2008 Aug 29.
Yeung M, Durocher D.
Engineering a DNA damage response without DNA damage.
Genome Biol. 2008;9(7):227.
Zhang W, Durocher D.
Dun1 counts on Rad53 to be turned on.
Mol Cell. 2008 Jul 11;31(1):1-2.
Fu Y, Zhu Y, Zhang K, Yeung M, Durocher D, Xiao W.
Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.
Cell. 2008 May 16;133(4):601-11.
Macrae CJ, McCulloch RD, Ylanko J, Durocher D, Koch CA.
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation.
DNA Repair (Amst). 2008 Feb 1;7(2):292-302.
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase.
Science [DOI: 10.1126/science.1150034]
Kanellis P, Gagliardi M, Banath JP, Szilard RK, Nakada S, Galicia S, Sweeney FD, Cabelof DC, Olive PL, Durocher D.
A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions.
PLoS Genet. 2007 Aug 10;3(8):e134.
PubMed abstract
Reprint
Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length.
J Cell Sci. 2006 Dec 15;119(Pt 24):5178-92.
PubMed abstract
Szilard RK, Durocher D.
Telomere protection: an act of God.
Curr Biol. 2006 Jul 25;16(14):R544-6.
PubMed abstract
Downey M, Durocher D.
GammaH2AX as a checkpoint maintenance signal.
Cell Cycle. 2006 Jul;5(13):1376-81. Epub 2006 Jul 1.
PubMed abstract
Blake D, Luke B, Kanellis P, Jorgensen P, Goh T, Penfold S, Breitkreutz BJ, Durocher D, Peter M, Tyers M.
The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae.
Genetics. 2006 Jun 4.
PubMed abstract | Text on genetics.org
Kolas NK, Durocher D.
DNA repair: DNA polymerase zeta and Rev1 break in.
Curr Biol. 2006 Apr 18;16(8):R296-9.
PubMed abstract
Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D.
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.
Cell. 2006 Mar 24;124(6):1155-68.
PubMed abstract
Downey M, Durocher D.
Chromatin and DNA repair: the benefits of relaxation.
Nat Cell Biol. 2006 Jan;8(1):9-10.
Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ.
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.
Nature. 2006 Jan 26;439(7075):497-501. Epub 2005 Nov 20.
PubMed abstract
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation.
Curr Biol. 2005 Aug 9;15(15):1364-75.
PubMed abstract
Tyers M, Brown E, Andrews DW, Bergeron JJ, Boone C, Bremner R, Bussey HA, Cross JC, Davies JE, Desjardins M, Dick JE, Dumont DJ, Durocher D, Ellison MJ, Golding GB, Gray MW, Harrington LA, Hieter PA, Johnston G, Kelvin DJ, McCarry BE, Michnick SW, Ouellette F, Pearlman RE, Penn LJ, Pelletier J, Rachubinski RA, Rennie PS, Rotin D, Rottapel R, Sadowski I, Sicheri F, Siminovitch L, Sonenberg N, Siu KW, Tremblay ML, Winegarden N, Wozniak RW, Wright GD, Woodgett JR.
Problems with co-funding in Canada.
Science. 2005 Jun 24;308(5730):1867.
Bernstein NK, Williams RS, Rakovszky ML, Cui D, Green R, Karimi-Busheri F, Mani RS, Galicia S, Koch CA, Cass CE, Durocher D, Weinfeld M, Glover JN.
The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase.
Mol Cell. 2005 Mar 4;17(5):657-70.
PubMed abstract
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.
EMBO J. 2004 Oct 1;23(19):3874-85. Epub 2004 Sep 23.
PubMed abstract | Text on PubMed Central
Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability.
Curr Biol. 2003 Sep 16;13(18):1583-95.
PubMed abstract
Durocher D, Smerdon SJ, Yaffe MB, Jackson SP.
The FHA domain in DNA repair and checkpoint signaling.
Cold Spring Harb Symp Quant Biol. 2000;65:423-31. Review.
Durocher D.
Bacterial signal transduction: a FHAscinating glimpse at the origins of phospho-dependent signal transduction.
Trends Microbiol. 2003 Feb;11(2):67-8.
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.
Mol Cell. 2002 May;9(5):1045-54.
PubMed abstract
Durocher D, Jackson SP. Related Articles, Links Abstract
The FHA domain.
FEBS Lett. 2002 Feb 20;513(1):58-66. Review.
PubMed abstract
Ho Y, Gruhler A, Heilbut A, Bader GD, Moore L, Adams SL, Millar A, Taylor P, Bennett K, Boutilier K, Yang L, Wolting C, Donaldson I, Schandorff S, Shewnarane J, Vo M, Taggart J, Goudreault M, Muskat B, Alfarano C, Dewar D, Lin Z, Michalickova K, Willems AR, Sassi H, Nielsen PA, Rasmussen KJ, Andersen JR, Johansen LE, Hansen LH, Jespersen H, Podtelejnikov A, Nielsen E, Crawford J, Poulsen V, Sorensen BD, Matthiesen J, Hendrickson RC, Gleeson F, Pawson T, Moran MF, Durocher D, Mann M, Hogue CW, Figeys D, Tyers M.
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
Nature. 2002 Jan 10; 415(6868):180-3
PubMed abstract
DNA-PK, ATM and ATR, variations on a theme?
Curr Opin Cell Biol . 2001 Apr 13 (2):225-31. Review.
PubMed abstract
Regulation of DNA damage signalling by FHA domains.
Cold Spring Harbor Symposia on Quantitative Biology (2000) Review.
Durocher D, Taylor IA, Sarbassova D, Haire LH, Westcott SL, Jackson SP, Smerdon SJ and Yaffe MB.
The molecular basis of FHA domain: phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
Molecular Cell. 2000, 6:1169-1182
PubMed abstract | Text on molecule.org
The FHA domain is a modular phosphopeptide recognition motif.
Molecular Cell. 1999, 4:387-394
PubMed abstract | Text on molecule.org